In my dynasty I have my defense set up on a multiple playbook so I can adapt personnel year to year. I found that SSs were very easy to recruit at a high level when contrasted with linebackers and anyway it's more practical because 10 and 11 personnel are just the way things are done by most offenses now, real life or gaming; online or offline.
I had been running a 3-3-5 with 3-4 and 4-3 for changeup but I'm now running 4-2-5 because I've continued to have great defensive linemen (currently have two 90+ ovr 300+lb DTs) and I only have two great linebackers; plus it makes more sense considering how difficult I've personally found it to recruit defensive ends over 260.
I've also just typically been intrigued by the 4-2-5 because it's different variations in execution have led to success at TCU and VT for a long time and recently Ok State and Baylor.
There are some cool blitzes and change ups in a 3-3-5 okie and split, as well, though. And i started running the bear front as my primary after watching some VT games. You can get a look more realistic to what they do by just hitting the show blitz toggle in game on a 4-2-5 normal look,though.
And 3-3-5 stacks ability to switch to a 3-5-3 makes it such that you don't really need traditional base defenses in your playbook if you don't want them.
3-4 has a good capacity for defending various offensive sets, especially if you can play zone and your linebackers are fast. It's just that running it realistically can be difficult because of the relative dearth (in my experience) of large defensive ends.
The great thing about the spread defenses is that you're less likely to need to switch formations whereas with 4-3 and 3-4 you are guaranteed to have to run nickel and probably dime sometime during a game.
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