Usually if his first read is a throw inside the hashes and he stares it down by the time he comes off of it the corners will be in a good place to play the curls but @TXHusker are you robbing the field in 2x2 or just sticking with what side the defensive formation aligns you to ?
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The short answer is yes, any time I user control the FS (which is probably 90% of the game) I rob towards the passing strength of the formation or towards the field vs a balanced set. I just feel like I can cover more ground that way and in both my Inverted Cover 2 and Cover 3 (which I treat just like inverted Cover 2), I trust my corners to cover deep allowing me to take more chances jumping short/intermediate passes and help in the run game. That's pretty much 90% of my defense, just user controlling the FS and jumping short/intermediate routes and run support. I get a lot of interceptions taking away the first read and forcing someone to throw late to a secondary option
However, 2x2 with the ball on the hash is one of the times I find myself user controlling a player other than the FS. Since so many people love throwing quick to the backside on the hash, I'll typically user control my backside strong safety with inside leverage on #2. I'll carry him vertical if he goes vertical, if he crosses my face I'll let him go and track #1. I do the same vs 3x2 Empty sets.
Generally speaking, I'll just play the passing strength. Carry the innermost receiver vertical, if he does anything else, let him go and wait for crossers to try and jump for a pick. It works for me, but it takes a lot of feel for the game and a lot of anticipation. Most users get into fairly predictable patterns. I trust my CPU CBs to cover me deep in both Cover 3 and Inverted Cover 2 (which is essentially the same coverage for me) and that lets me take a lot of risks going for INTs and attacking the run game.
The simplicity is nice. I don't concern myself with much man coverage and I never press, which I feel is unique for most users in NCAA. I treat my defense much the same way as Cover 4. Pattern read and run support with the FS.